The stability region of the large virulence plasmid of Shigella flexneri encodes an efficient postsegregational killing system.

@article{Sayeed2000TheSR,
  title={The stability region of the large virulence plasmid of Shigella flexneri encodes an efficient postsegregational killing system.},
  author={Sameera Sayeed and Lucretia Reaves and Lyndsay Radnedge and S. Austin},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 9},
  pages={2416-21}
}
The large virulence plasmid pMYSH6000 of Shigella flexneri contains a determinant that is highly effective in stabilizing otherwise unstable plasmids in Escherichia coli. Expression of two small contiguous genes, mvpA and mvpT (formerly termed STBORF1 and STBORF2), was shown to be sufficient for stability. Mutations in mvpT abolished plasmid stability, and plasmids expressing only mvpT killed the cells unless mvpA was supplied from a separate plasmid or from the host chromosome. When… CONTINUE READING