The stability of human acidic β-crystallin oligomers and hetero-oligomers

@article{Bateman2003TheSO,
  title={The stability of human acidic $\beta$-crystallin oligomers and hetero-oligomers},
  author={O. Bateman and R. Sarra and S. T. V. Genesen and G. Kapp{\'e} and N. Lubsen and C. Slingsby},
  journal={Experimental Eye Research},
  year={2003},
  volume={77},
  pages={409-422}
}
Abstract Crystallins are bulk structural proteins of the eye lens that have to last a life time. They gradually become modified with age, denature and form light scattering centres. High thermodynamic and kinetic stability of the crystallins enables them to resist unfolding and delay cataract. Here we have made recombinant human βA1-, βA3-, and βA4-crystallins. The βA3-crystallin formed higher oligomers that lead to precipitation at ambient temperature. Heat-induced precipitation of βA3… Expand
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Crystallins and Their Complexes.
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