The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination

@article{Inoue2015TheSO,
  title={The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination},
  author={Daichi Inoue and Koutarou Nishimura and Hiroko Kozuka-Hata and Masaaki Oyama and Toshio Kitamura},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={2257-2260}
}
Additional sex combs like transcriptional regulator 1 (ASXL1) is indispensable for normal development and myeloid differentiation. Mutation of ASXL1 is one of the most common mutations among various myeloid malignancies, especially in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia, and is an independent poor prognostic factor among patients with MDS. We previously demonstrated that the expression of C-terminal-truncated ASXL1 inhibited myeloid differentiation and induced an… CONTINUE READING
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