The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection.

Abstract

Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). DPD activity in tumor tissue may consequently serve as a predictive factor for sensitivity to 5-FU. The purpose of this study was to elucidate the stability of DPD activity over time in resected colorectal cancer tissue. DPD activity was… (More)

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