The stability of a novel carbapenem antibiotic, meropenem (SM-7338), in a solid state formulation for injection.

Abstract

A formulation of meropenem, a novel carbapenem antibiotic for injection, was developed as a vial filled with a mixture of meropenem and dried sodium carbonate. During the design phase, we studied the effect of water in the formulation on the stability of meropenem in the solid state. Meropenem is obtained as trihydrate, whose moisture content is 12.35% and… (More)

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