The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons

  title={The spotted gar genome illuminates vertebrate evolution and
facilitates human-to-teleost comparisons},
  author={Ingo Braasch and Andrew R. Gehrke and Jeramiah J Smith and Kazuhiko Kawasaki and Tereza Manousaki and J{\'e}r{\'e}my Pasquier and Angel Amores and Thomas Desvignes and Peter Batzel and Julian M Catchen and Aaron M. Berlin and Michael S. Campbell and Daniel Barrell and Kyle J. Martin and John Frederick Mulley and Vydianathan Ravi and Alison Ping Lee and Tetsuya Nakamura and Domitille S Chalopin and Shaohua Fan and Dustin J. Wcisel and Cristian Ca{\~n}estro and Jason Sydes and Felix Emile Gastonguay Beaudry and Yi Sun and Jana Hertel and Michael J Beam and Mario Fasold and Mikio Ishiyama and Jeremy A Johnson and Steffi Kehr and Marcia Lara and John H Letaw and Gary W. Litman and Ronda T. Litman and Masato Mikami and Tatsuya Ota and Nil Ratan Saha and Louise J S Williams and Peter F. Stadler and Han Wang and John Stewart Taylor and Quenton C Fontenot and Allyse M Ferrara and Stephen M. J. Searle and Bronwen L. Aken and Mark Yandell and Igor Schneider and Jeffrey A Yoder and Jean-Nicolas Volff and Axel Meyer and Chris T Amemiya and Byrappa Venkatesh and Peter W H Holland and Yann Guiguen and Julien Bobe and Neil H. Shubin and Federica di Palma and Jessica Alf{\"o}ldi and Kerstin Lindblad-Toh and John H Postlethwait},
  booktitle={Nature Genetics},
To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous… CONTINUE READING
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