The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial.

@article{Meretoja2014TheSS,
  title={The spot sign and tranexamic acid on preventing ICH growth--AUStralasia Trial (STOP-AUST): protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial.},
  author={Atte Meretoja and Leonid Churilov and Bruce C V Campbell and Richard I. Aviv and Nawaf Yassi and Christen D. Barras and Peter L Mitchell and Bernard Yan and Harshal Nandurkar and Christopher Bladin and Tissa Wijeratne and Neil James Spratt and Jim Jannes and Jonathan William Sturm and Jayantha S. Rupasinghe and Jorge Zavala and Andrew Lee and Timothy John Kleinig and Romesh Markus and Candice Delcourt and Neil Mahant and Mark William Parsons and Christopher Royce Levi and Craig S Anderson and Geoffrey Alan Donnan and Stephen M Davis},
  journal={International journal of stroke : official journal of the International Stroke Society},
  year={2014},
  volume={9 4},
  pages={519-24}
}
RATIONALE No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions. AIM The study aims to test the hypothesis that intracerebral hemorrhage patients selected with computed tomography angiography contrast extravasation 'spot sign' will have lower rates of hematoma growth when treated with intravenous tranexamic acid within 4.5-hours of… CONTINUE READING
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