The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile.

@article{Phetcharaburanin2014TheSP,
  title={The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile.},
  author={Jutarop Phetcharaburanin and Huynh A. Hong and Claire Colenutt and Irene Bianconi and Lluis Sempere and Patima Permpoonpattana and Karen Smith and Marcin Dembek and Sisareuth Tan and Marie-Cl{\'e}mence Brisson and Alain R. Brisson and Neil F Fairweather and Simon M Cutting},
  journal={Molecular microbiology},
  year={2014},
  volume={92 5},
  pages={1025-38}
}
The BclA protein is a major component of the outermost layer of spores of a number of bacterial species and Clostridium difficile carries three bclA genes. Using insertional mutagenesis each gene was characterized and spores devoid of these proteins had surface aberrations, reduced hydrophobicity and germinated faster than wild-type spores. Therefore the BclA proteins were likely major components of the spore surface and when absent impaired the protective shield effect of this outermost layer… CONTINUE READING
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