The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

@inproceedings{Linares2015TheSR,
  title={The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation},
  author={Anthony J. Linares and Chia-Ho Lin and Andrey Damianov and Katrina L Adams and Bennett G. Novitch and Douglas L. Black},
  booktitle={eLife},
  year={2015}
}
The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many synaptic and cytoskeletal proteins during differentiation of neuronal progenitor cells (NPCs) into early neurons. However, the role of the earlier PTBP1 program in embryonic stem cells (ESCs) and NPCs was not clear. We show that PTBP1 controls a program of neuronal gene expression that includes the transcription factor… CONTINUE READING
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