The splicing factor U1C represses EWS/FLI-mediated transactivation.

  title={The splicing factor U1C represses EWS/FLI-mediated transactivation.},
  author={Lori L. Knoop and Suzanne J. Baker},
  journal={The Journal of biological chemistry},
  volume={275 32},
EWS is an RNA-binding protein involved in human tumor-specific chromosomal translocations. In approximately 85% of Ewing's sarcomas, such translocations give rise to the chimeric gene EWS/FLI. In the resulting fusion protein, the RNA binding domains from the C terminus of EWS are replaced by the DNA-binding domain of the ETS protein FLI-1. EWS/FLI can function as a transcription factor with the same DNA binding specificity as FLI-1. EWS and EWS/FLI can associate with the RNA polymerase II… CONTINUE READING


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