The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation

@article{Jumaa1997TheSF,
  title={The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation},
  author={Hassan Jumaa and Peter J. Nielsen},
  journal={The EMBO Journal},
  year={1997},
  volume={16}
}
SRp20 is a member of the highly conserved SR family of splicing regulators. Using a variety of reporter gene constructs, we show that SRp20 regulates alternative splicing of its own mRNA. Overexpression of SRp20 results in a reduction in the level of exon 4‐skipped SRp20 transcripts and activates the production of transcripts containing exon 4. These exon 4‐included transcripts encode a truncated protein lacking the C‐terminal RS domain. We provide evidence that SRp20 probably enhances the… 
Regulation of SRp20 exon 4 splicing.
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TLDR
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TLDR
Using various minigene constructs containing the terminal retained intron and flanking exons, a number of exonic splicing enhancer elements responding specifically to SC35 are identified, and an inverse correlation between affinity of SC35 and enhancer strength is shown, which highlights the existence of a complex network of self- and cross-regulatory mechanisms between splicing regulators.
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TLDR
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TLDR
These results, and the fact that the exon 3 and 4 ESE sequences are conserved in vertebrates, strongly suggest that the alternative splicing of intron 3 represents an important step in the regulation of the expression of 9G8.
SR Proteins Induce Alternative Exon Skipping through Their Activities on the Flanking Constitutive Exons
TLDR
It is shown that SR protein-induced exon skipping depends on their prevalent actions on a flanking constitutive exon and requires collaboration of more than one SR protein, and may constitute a key strategy for synergism with other splicing regulators in establishing tissue-specific alternative splicing critical for cell differentiation programs.
Characterization of SRp46, a Novel Human SR Splicing Factor Encoded by a PR264/SC35 Retropseudogene
TLDR
It is demonstrated, for the first time, that an SR splicing factor, which represents a novel member of the SR family, is encoded by a functional retropseudogene.
Regulation of Splicing Factors by Alternative Splicing and NMD Is Conserved between Kingdoms Yet Evolutionarily Flexible
TLDR
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    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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TLDR
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TLDR
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