The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.

@article{Valadkhan2010TheSP,
  title={The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.},
  author={Saba Valadkhan and Yasaman Jaladat},
  journal={Proteomics},
  year={2010},
  volume={10 22},
  pages={4128-41}
}
Almost all primary transcripts in higher eukaryotes undergo several splicing events and alternative splicing is a major factor in generating proteomic diversity. Thus, the spliceosome, the ribonucleoprotein assembly that performs splicing, is a highly critical cellular machine and as expected, a very complex one. Indeed, the spliceosome is one of the largest, if not the largest, molecular machine in the cell with over 150 different components in human. A large fraction of the spliceosomal… CONTINUE READING

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Spliceosome structure and function.

Cold Spring Harbor perspectives in biology • 2011
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