The spleen in the sickling disorders: an update

@article{Khatib2008TheSI,
  title={The spleen in the sickling disorders: an update},
  author={Rana Khatib and Raja M Rabah and Sharada A. Sarnaik},
  journal={Pediatric Radiology},
  year={2008},
  volume={39},
  pages={17-22}
}
In early life, patients with sickle cell disease (SCD) can have acute, life-threatening emergencies related to splenic hypofunction (overwhelming bacterial sepsis), as well as anemic crises from acute splenic sequestration because of sudden pooling of blood in the spleen. The landmark penicillin prophylaxis study in 1985 showed a remarkable decrease in mortality from sepsis in young children with SCD who were treated with oral penicillin prophylaxis compared to placebo. Since that study… Expand
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