The spleen in the sickling disorders: an update

@article{Khatib2008TheSI,
  title={The spleen in the sickling disorders: an update},
  author={R. Khatib and R. Rabah and S. Sarnaik},
  journal={Pediatric Radiology},
  year={2008},
  volume={39},
  pages={17-22}
}
In early life, patients with sickle cell disease (SCD) can have acute, life-threatening emergencies related to splenic hypofunction (overwhelming bacterial sepsis), as well as anemic crises from acute splenic sequestration because of sudden pooling of blood in the spleen. The landmark penicillin prophylaxis study in 1985 showed a remarkable decrease in mortality from sepsis in young children with SCD who were treated with oral penicillin prophylaxis compared to placebo. Since that study… Expand
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Prevalence and predictive factors of splenic sequestration crisis among 423 pediatric patients with sickle cell disease in Tunisia.
TLDR
The high prevalence of SSC in SCD and the high frequency of recurrence after a first episode were confirmed and were intimately linked to the presence of splenomegaly, chronic pallor revealing the disease as well as reticulocytosis. Expand
Spleen histology in children with sickle cell disease and hereditary spherocytosis: hints on the disease pathophysiology.
TLDR
SCD spleens display greater histologic effacement than HS, and SCD-related changes suggest impaired function due to vascular damage, which may contribute to guide the clinical management of patients. Expand
Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease.
TLDR
Altered SCD splenic morphological characteristics result in an impaired systemic immune response, and this model suggests that functional asplenia from infarctions may be a major contributor to increased infectious mortality in sickle-cell disease. Expand
Carriage of encapsulated bacteria in Gabonese children with sickle cell anaemia.
  • F. Schaumburg, B. Biallas, +8 authors A. Adegnika
  • Biology, Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2013
TLDR
Carriage and resistance rates are similar in children with and without SCA, and data provide the basis to guide empiric therapy of invasive diseases caused by S. pneumoniae, Staph. Expand
Non-traumatic spleen disorders in children. Assessment by imaging.
TLDR
The aim was to show the behaviour of the spleen in children using the different imaging techniques: its normal anatomy, the principal anatomical variants and the most common spleen disorder correlating with clinical symptoms, serology and histology. Expand
Non-traumatic spleen disorders in children. Assessment by imaging.
TLDR
The behaviour of the spleen in children is shown using the different imaging techniques: its normal anatomy, the principal anatomical variants and the most common spleen disorder correlating with clinical symptoms, serology and histology. Expand
Current sickle cell disease management practices in Nigeria.
TLDR
The care available for SCD in Nigeria is still suboptimal and there is an urgent need for concerted effort to tackle the problem, but to make a significant impact on the burden of the disease would require more focus at the primary care level. Expand
WEB-BASED MONITORING OF PAIN MANAGEMENT IN ADOLESCENT AND YOUNG ADULT SICKLE CELL PATIENTS THROUGH DAILY SELF-ASSESSMENT
TLDR
The implementation of a web-based application to monitor daily pain levels is relevant to public health because it is likely to provide medical teams with the tools necessary to track patient pain levels more precisely and to enable healthcare providers to be more proactive with regard to pain management in patients with SCD. Expand
Incidence of Sickle Cell Anaemia among Children Attending Maryam Abacha Women and Children Hospital, Sokoto
TLDR
Improved knowledge regarding Sickle cell anaemia disease and its comprehensive care among Nigerian physicians will enhance quality of care for affected childrens and policy for regular genotype test by government and other stakeholders before marriage among Nigerians will help to prevent the disease. Expand
Abdominal ultrasound with scintigraphic and clinical correlates in infants with sickle cell anemia: baseline data from the BABY HUG trial.
TLDR
In infants with sickle cell anemia, sonographic spleen volume does not reflect function, but increased renal volume correlates with GFR and is consistent with hyperfiltration. Expand
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