The spleen in local and systemic regulation of immunity.

  title={The spleen in local and systemic regulation of immunity.},
  author={Vincenzo Bronte and Mikael J Pittet},
  volume={39 5},
The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ for iron metabolism and erythrocyte homeostasis. Also, immune and hematopoietic functions have been recently unveiled for the mouse spleen, suggesting additional roles for this secondary lymphoid organ. Here we discuss the integration of the spleen in the regulation of immune responses locally and in the whole body and present the relevance of findings for our understanding of inflammatory and… CONTINUE READING
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