The spleen in HIV infection--morphological evidence of HIV-associated macrophage dysfunction.


One-hundred spleens from HIV-infected patients which were studied by conventional morphological and immunohistochemical methods exhibited alterations in lymphatic tissue as well as in the mononuclear phagocyte system (MPS); these were probably related directly to HIV infection of lymphocytes and MPS cells. There was ample evidence of impairment of… (More)


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