The spine neck filters membrane potentials.

@article{Araya2006TheSN,
  title={The spine neck filters membrane potentials.},
  author={Roberto Barraza Araya and Jiang Jiang and Kenneth B Eisenthal and Rafael Yuste},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 47},
  pages={
          17961-6
        }
}
Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine neck. Here we investigate whether the spine neck also isolates inputs electrically. Using two-photon uncaging of glutamate on spine heads from mouse layer-5 neocortical pyramidal… CONTINUE READING

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