The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.

@article{Geiler1996TheSP,
  title={The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment.},
  author={Stefan Gei\ssler and Gislene Pereira and Anne Spang and Michael Knop and Sylvie Sou{\`e}s and John V. Kilmartin and Elmar Schiebel},
  journal={The EMBO journal},
  year={1996},
  volume={15 15},
  pages={3899-911}
}
Tub4p is a novel tubulin found in Saccharomyces cerevisiae. It most resembles gamma-tubulin and, like it, is localized to the yeast microtubule organizing centre, the spindle pole body (SPB). In this paper we report the identification of SPC98 as a dosage-dependent suppressor of the conditional lethal tub4-1 allele. SPC98 encodes an SPB component of 98 kDa which is identical to the previously described 90 kDa SPB protein. Strong overexpression of SPC98 is toxic, causing cells to arrest with a… CONTINUE READING
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