The spinal biology in humans and animals of pain states generated by persistent small afferent input.

@article{Yaksh1999TheSB,
  title={The spinal biology in humans and animals of pain states generated by persistent small afferent input.},
  author={Tony L. Yaksh and X Y Hua and Iveta Kalcheva and Natsuko Nozaki-Taguchi and Martin Marsala},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 14},
  pages={7680-6}
}
Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persistent small afferent input. The allodynia reflects a central sensitization. The spinal pharmacology of these pain states has been defined in the unanesthetized rat prepared with… CONTINUE READING

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