The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.

@article{Gierer2013TheSP,
  title={The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.},
  author={Stefanie Gierer and Stephanie Bertram and Franziska Kaup and Florian Wrensch and Adeline Heurich and Annika Kr{\"a}mer-K{\"u}hl and Kathrin Welsch and Michael F. Winkler and Benjamin De Meyer and Christian Drosten and Ulf Dittmer and Thomas von Hahn and Graham Simmons and Heike Hofmann and Stefan P{\"o}hlmann},
  journal={Journal of virology},
  year={2013},
  volume={87 10},
  pages={5502-11}
}
The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose a significant threat to public health. The elucidation of hCoV-EMC interactions with host cells is critical to our understanding of the pathogenesis of this virus and to the identification of targets for antiviral intervention. Here we investigated the viral and cellular determinants governing hCoV-EMC entry into host cells. We found that the spike protein of hCoV-EMC (EMC-S… CONTINUE READING
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