The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells.

@article{DazSalinas2013TheSP,
  title={The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells.},
  author={Marco Aurelio D{\'i}az-Salinas and Pedro A. Romero and Rafaela Espinosa and Yasutaka Hoshino and Susana Gonz{\'a}lez L{\'o}pez and Carlos F Arias},
  journal={Journal of virology},
  year={2013},
  volume={87 3},
  pages={1658-63}
}
Rotaviruses are internalized into MA104 cells by endocytosis, with different endocytic pathways used depending on the virus strain. The bovine rotavirus UK strain enters cells through a clathrin-mediated endocytic process, while the simian rhesus rotavirus (RRV) strain uses a poorly defined endocytic pathway that is clathrin and caveolin independent. The viral surface protein VP7 and the spike protein VP4 interact with cellular receptors during cell binding and penetration. To determine the… CONTINUE READING
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