The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE2 production in response to TNF‐α

@article{Pettus2003TheSK,
  title={The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE2 production in response to TNF‐$\alpha$},
  author={Benjamin J. Pettus and Jacek Bielawski and Anna Maria Porcelli and Davis L. Reames and Korey R. Johnson and Jason D. Morrow and Charles E. Chalfant and Lina M. Obeid and Yusuf A. Hannun},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={1411 - 1421}
}
In this study we addressed the role of sphingolipid metabolism in the inflammatory response. In a L929 fibroblast model, tumor necrosis factor‐α (TNF) induced prostaglandin E2 (PGE2) production by 4 h and cyclooxygenase‐2 (COX‐2) induction as early as 2 h. This TNF‐induced PGE2 production was inhibited by NS398, a COX‐2 selective inhibitor. GC‐MS analysis revealed that only COX‐2‐generated prostanoids were produced in response to TNF, thus providing further evidence of COX‐2 selectivity. As… 
Effect of sphingosine kinase 1 inhibition on blood pressure
  • H. Furuya, M. Wada, +4 authors T. Kawamori
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
TLDR
The results show that lack of SphK1 expression did not exacerbate angiotensin II (Ang II)‐induced acute hypertension, whereas celecoxib, a COX‐2 inhibitor, augmented and sustained higher BP in mice, suggesting that SphK 1 inhibition may be a promising strategy for cancer chemoprevention with lack of the adverse cardiovascular side effects associated with coxibs.
Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity
TLDR
It is reported for the first time that S1P potently suppresses LT biosynthesis in Ca2+‐ionophore–stimulated intact human neutrophils and targeting the 5‐LO pathway is an important mechanism to explain S 1P‐mediated pathophysiologic effects.
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
TLDR
A role of sphingosine kinase type 1 activation in proinflammatory signalling and of SPHK1 basal activity in survival of A549 lung carcinoma cells is demonstrated.
Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching
  • Eugene Y. Kim, J. Sturgill, +10 authors S. Spiegel
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
TLDR
It is found that ligation of CD40 activates and translocates SphK1 to the plasma membrane, leading to generation of S1P, which is important for CD40‐mediated B cell activation and regulation of humoral responses and suggest that targeting SphK 1 might be a useful therapeutic approach to control antigen‐specific IgE production.
The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate
TLDR
These two pathways are independent but coordinated, resulting in synergistic induction of PGE2, and the combination of both S1P and C1P recapitulates the temporal and spatial activation of cPLA2 and with COX-2 seen IL-1β.
A role for sphingosine kinase 1 in dextran sulfate sodium‐induced colitis
  • A. Snider, T. Kawamori, +4 authors L. Obeid
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
TLDR
Inhibition of SK1 may prove to be a valuable therapeutic target by inhibiting sys‐temic and local inflammation in IBD by implicating for the first time SK1 in TNF‐α‐mediated COX‐2 induction in vivo.
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages.
TLDR
It is shown that LPS increases cellular levels of SK1 message and protein and is accompanied by increased SK activity and generation of S1P, indicating that there is a dual and distinct role for SK1 and S1p in the TNF and the LPS inflammatory pathways.
Effects of sphingosine‐1‐phosphate and ceramide‐1‐phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus
TLDR
The results demonstrate that intestinal smooth muscle cells represent a major target for both C1P and S1P activity, and the sustained elevated concentration of the two bioactive sphingolipids in this tissue could at least in part explain postoperative intestinal dysmotility.
Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts.
TLDR
In SEMFs, S1P amplifies IL-1beta-induced COX-2 expression through increased mRNA stability and activation of SEMFs may contribute to intestinal inflammation and carcinogenesis.
Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation*
TLDR
It is found that loss of SK1 potentiates induction of the chemokine RANTES in HeLa cells stimulated with TNF-α despite RantES induction being highly dependent on the NF-κB pathway.
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