The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

@article{Hisano2011TheS1,
  title={The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.},
  author={Yu Hisano and Naoki Kobayashi and Atsuo Kawahara and Akihito Yamaguchi and Tsuyoshi Nishi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 3},
  pages={1758-66}
}
FTY720 is a novel immunomodulating drug that can be phosphorylated inside cells; its phosphorylated form, FTY720-P, binds to a sphingosine 1-phosphate (S1P) receptor, S1P(1), and inhibits lymphocyte egress into the circulating blood. Although the importance of its pharmacological action has been well recognized, little is known about how FTY720-P is released from cells after its phosphorylation inside cells. Previously, we showed that zebrafish Spns2 can act as an S1P exporter from cells and is… CONTINUE READING
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Na Human SPNS2 Transports FTY720-P

  • K. Takabe, R. H. Kim, J. C. Allegood, P. Mitra, S. Ramachandran
  • J. Biol
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