The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.

Abstract

Agonists of the sphingosine-1-phosphate (S1P) receptors, like fingolimod (FTY720), are a novel class of immunomodulators. Administration of these compounds prevents the egress of lymphocytes from primary and secondary lymphoid organs causing peripheral blood lymphopenia. Although it is well established that lymphopenia is mediated by S1P receptor type 1… (More)
DOI: 10.1016/j.intimp.2011.07.004

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@article{Tarrasn2011TheSR, title={The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice.}, author={Gema Tarras{\'o}n and Mariona Aul{\'i} and Sanam Mustafa and Vladislav A Dolgachev and Mar{\'i}a Teresa Dom{\'e}nech and Neus Prats and Maria Dominguez and R. L{\'o}pez and N{\'u}ria Aguilar and Marta Calbet and Merc{\`e} Pont and Graeme Milligan and Steven L. Kunkel and N{\'u}ria Godessart}, journal={International immunopharmacology}, year={2011}, volume={11 11}, pages={1773-9} }