The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling.

@article{Aydin2010TheSP,
  title={The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling.},
  author={Memduh Aydin and Keith L. Downing and Guillermo Villegas and Xinhua Zhang and Rowena Escolar Chua and Arnold Melman and Michael E Disanto},
  journal={BJU international},
  year={2010},
  volume={106 4},
  pages={
          562-71
        }
}
OBJECTIVES To examine the effect of partial urethral obstruction (PUO) on the sphingosine-1-phosphate (S1P, a bioactive lipid shown to modulate smooth muscle, SM) pathway in the bladders of male rats, and to determine the effect of PUO on the RhoA/Rho-kinase (ROK) pathway, and whether there is a molecular cross-talk with the S1P pathways associated with bladder overactivity (S1P1-S1P3, where S1P1 is associated with nitric oxide-mediated SM relaxation, and S1P2 and S1P3 receptors are associated… CONTINUE READING
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