The spermatid micronucleus test with the dissection technique detects the germ cell mutagenicity of acrylamide in rat meiotic cells.

@article{Lhdetie1994TheSM,
  title={The spermatid micronucleus test with the dissection technique detects the germ cell mutagenicity of acrylamide in rat meiotic cells.},
  author={Jaana L{\"a}hdetie and A Suutari and T Sj{\"o}blom},
  journal={Mutation research},
  year={1994},
  volume={309 2},
  pages={
          255-62
        }
}
As a part of the development and validation of the spermatid micronucleus test (SMNT) in the project 'Detection of Germ Cell Mutagens' sponsored by the CEC we studied the mutagenicity of acrylamide (AA) and mitomycin C (MMC). Of two alternative techniques, we used the 'dissection technique' based on microdissection of seminiferous tubules offering a narrow window for evaluation of cell stage sensitivity, and including DNA-specific staining and scoring. AA given as a single injection of 50 or… CONTINUE READING

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