The speed of change: towards a discontinuity theory of immunity?

  title={The speed of change: towards a discontinuity theory of immunity?},
  author={Thomas Pradeu and S{\'e}bastien Jaeger and {\'E}ric Vivier},
  journal={Nature Reviews Immunology},
Immunology — though deeply experimental in everyday practice — is also a theoretical discipline. Recent advances in the understanding of innate immunity, how it is triggered and how it shares features that have previously been uniquely ascribed to the adaptive immune system, can contribute to the refinement of the theoretical framework of immunology. In particular, natural killer cells and macrophages are activated by transient modifications, but adapt to long-lasting modifications that occur… 

The sensory immune system: a neural twist to the antigenic discontinuity theory

  • S. Nataf
  • Biology
    Nature Reviews Immunology
  • 2014
It is argued that the current theoretical conception of immunity is possibly biased by an incomplete picture of the so-called ‘immune recognition’ process, and a parallel could be established between the sensory nervous system and the afferent arm of immunity, and the term “immune perception” is proposed to describe the function of ‘ immune recognition”.

Immunity by equilibrium

  • G. Eberl
  • Biology
    Nature Reviews Immunology
  • 2016
A model of immunity is proposed that is based on equilibrium, in which the healthy immune system is always active and in a state of dynamic equilibrium between antagonistic types of response, which determines tolerance, protective immunity and inflammatory pathology.

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  • Biology
    Studies in history and philosophy of biological and biomedical sciences
  • 2020

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A quantitative model of the regulation of nonspecific activation inspired by Bayesian inference is introduced, which captures known behaviors of innate immune cells, including adaptation to changing environments and the development of hyposensitivity after prolonged exposure to activating signals.



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NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.

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  • D. Pardoll
  • Biology, Medicine
    Annual review of immunology
  • 2003
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Longer subcutaneous infusion of low doses of peptide by means of osmotic pumps transforms mature T cells into CD4+25+ suppressor cells that can persist for long periods of time in the absence of antigen and confer specific immunologic tolerance upon challenge with antigen.

Langerhans cells are precommitted to immune tolerance induction

Antigen-dependent interactions between T lymphocytes and dendritic cells (DCs) can produce two distinct outcomes: tolerance and immunity. It is generally considered that all DC subsets are capable of

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Evidence that ligands for one key NK receptor, NKG2D, are induced by the DNA damage response, which is activated in cells exposed to genotoxic stress, suggests a new concept for how diseased cells are discriminated by the immune system.

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IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

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