The purpose of this study was to analyze the spectrum of presumed tubercular uveitis in Tunisia, North Africa. We retrospectively reviewed the clinical records of 38 patients (65 eyes) diagnosed with presumed tubercular uveitis at two referral centers in Tunisia, between January 2009 and December 2011. Mean age at presentation was 42.7 years. Twenty-four patients were women (63.2 %) and 14 (36.8 %) were men. Twenty-three eyes (35.4 %) had posterior uveitis, 21 eyes (32.3 %) had intermediate uveitis, 13 eyes (20 %) had panuveitis, and 8 eyes (12.3 %) had anterior uveitis. Ocular findings included vitritis in 67.7 % of eyes, posterior synechiae in 47.7 %, multifocal non-serpiginoid choroiditis in 23.1 %, multifocal serpiginoid choroiditis in 21.5 %, periphlebitis in 21.5 %, and mutton-fat keratic precipitates in 20 %. Anti-tubercular treatment was prescribed in 33 patients (86.8 %) and was associated with systemic corticosteroids in 20 patients (52.6 %) and periocular injections of corticosteroids in four patients (10.5 %). After a mean follow-up of 14.2 months (range, 10–58), inflammation was controlled, with a significant improvement in visual acuity (VA) (p = 0.028). However, recurrences developed in two patients (5.3 %). Final VA was better than 20/40 in 27 eyes (41.5 %) and less than 20/200 in five eyes (7.7 %). In Tunisia, all anatomic types are possible in tuberculosis-associated uveitis, but posterior and intermediate uveitis are more frequent. Vitritis, posterior synechiae, multifocal serpiginoid or non-serpiginoid choroiditis, and periphlebitis are the most common manifestations.