The spectrum of noncoeliac gluten sensitivity
@article{Aziz2015TheSO, title={The spectrum of noncoeliac gluten sensitivity}, author={Imran Aziz and Marios Hadjivassiliou and David S. Sanders}, journal={Nature Reviews Gastroenterology \&Hepatology}, year={2015}, volume={12}, pages={516-526} }
The past 5 years have seen an increase in the use of a gluten-free diet outside a diagnosis of coeliac disease or IgE-mediated wheat allergy. This trend has led to the identification of a new clinical entity termed noncoeliac gluten sensitivity (NCGS). In this Review, we discuss the evidence for NCGS as demonstrated by the results of double-blind, placebo-controlled dietary rechallenge studies. Furthermore, the characteristic phenotype of individuals with NCGS is described as well as the…
68 Citations
From coeliac disease to noncoeliac gluten sensitivity; should everyone be gluten free?
- MedicineCurrent opinion in gastroenterology
- 2016
Despite the rising use of a GFD further studies are required to clearly establish the extent and exclusivity of gluten in NCGS, and terms such as ‘noncoeliac wheat sensitivity’ have been suggested as a wider label to define the condition.
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- MedicineGastroenterology
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This study found no evidence for induction of symptoms by consumption of gluten in participants with self-reported NCGS and rather attributed symptoms to the fructans present in wheat, which concluded that fructan are more likely to induce the NCGS symptoms than gluten, despite the very small differences between the 3 interventions.
[Non-celiac Gluten Sensitivity].
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New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS.
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- Medicine
- 2020
It is suggested that patients with gluten sensitivity who are negative for celiac disease should be considered for nonceliac gluten sensitivity, and it is concluded that NCGS is a real clinical phenomenon that awaits its own diagnostic clinical criteria and specific laboratory markers.
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- 2020
It is unclear which components of wheat are responsible for symptom generation in noncoeliac wheat or gluten sensitivity, with further research required to elucidate the pathophysiology.
Neurological Dysfunction in Coeliac Disease and Non-Coeliac Gluten Sensitivity
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The neurological manifestations of CD and NCGS are similar and equally responsive to a GFD suggestive of common pathophysiological mechanisms.
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Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms alleviated by gluten free diet (GFD) in subject who do not meet the criteria for Celiac Disease or wheat allergy.
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The normal duodenal mucosa, the clinical presentation and laboratory diagnosis of Gluten-sensitive enteropathy, the duodinal intraepithelial lymphocytes and immunophenotype of GSE-associated lymphocytes, the GSE mimickers, the differences “across oceans” among guidelines in diagnosing GSE, and the use of a synoptic report for reporting duodal biopsies in both children and adults in the 21st century are reported.
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