The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.

@article{Orr2002TheSO,
  title={The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.},
  author={David Francis Orr and Tianbao Chen and Anders Johnsen and Rod Chalk and Keith Deans Buchanan and James M. Sloan and Pingfan Rao and Chris Shaw},
  journal={Proteomics},
  year={2002},
  volume={2 11},
  pages={1586-600}
}
The hypothesis that chromogranin A (CgA), a protein of neuroendocrine cell secretory granules, may be a precursor of biologically active peptides, rests on observed activities of peptide fragments largely produced by exogenous protease digestion of the bovine protein. Here we have adopted a modified proteomic strategy to isolate and characterise human CgA-derived peptides produced by endogenous prohormone convertases. Initial focus was on an insulinoma as previous studies have shown that CgA is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…