The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation.

@article{Sakata2006TheSO,
  title={The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation.},
  author={Yasuhiko Sakata and Nobutaka Koibuchi and Fan Hai Xiang and Joey M Youngblood and Caramai N. Kamei and Michael T. Chin},
  journal={Journal of molecular and cellular cardiology},
  year={2006},
  volume={40 2},
  pages={267-73}
}
CHF1/Hey2 null mice generated in different laboratories have discrepant cardiovascular phenotypes. To determine the effect of genetic background on phenotype, we backcrossed our knockout strain more than eight generations to the inbred strains BALB/c and C57BL/6. Knockout mice on these backgrounds showed disparate phenotypes. Mice on both backgrounds demonstrated ventricular septal defects (VSDs), tricuspid stenosis and mitral valve thickening, but at varying frequencies, suggesting a general… CONTINUE READING