The spectrum of behaviors influenced by serotonin

@article{Lucki1998TheSO,
  title={The spectrum of behaviors influenced by serotonin},
  author={Irwin Lucki},
  journal={Biological Psychiatry},
  year={1998},
  volume={44},
  pages={151-162}
}
  • I. Lucki
  • Published 1 August 1998
  • Psychology, Biology
  • Biological Psychiatry
View on Elsevier
doi.org
1,091 Citations
Highly Influential Citations
29
Background Citations
529
Methods Citations
8
Results Citations
13

1,091 Citations

Citation Type

Citation Type

Revisiting the behavioral genetics of serotonin: relevance to anxiety and depression
CHAPTER 4.13 – The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression
Genetics of emotional regulation: the role of the serotonin transporter in neural function
Serotonin – lipid interactions and their role in behavior
Serotonin and motherhood: From molecules to mood
Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin
TLDR
These findings provide unequivocal evidence on the pivotal role of central serotonin in anxiety and aggression and the impact of serotonin depletion in the brain on mouse behavior.
Genetic approaches for understanding the role of serotonin receptors in mood and behavior
Hallucinogens and Drosophila: linking serotonin receptor activation to behavior
Cognitive dysfunction in neuropsychiatric disorders: Selected serotonin receptor subtypes as therapeutic targets
Mechanisms underlying altered mood and cardiovascular dysfunction: The value of neurobiological and behavioral research with animal models
  • A. J. Grippo
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2009
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 99 REFERENCES
Reconciling the role of central serotonin neurons in human and animal behavior
  • P. Soubrié
  • Psychology, Biology
    Behavioral and Brain Sciences
  • 1986
TLDR
Whether anxiety reduction or increased impulsivity is more likely to account for animal behavioral changes associated with decreased serotonergic transmission is investigated, as well as the effects of manipulating central serotonin in experimental anxiety paradigms in animals (punishment, extinction, novelty).
Serotonin receptor specificity in anxiety disorders.
  • I. Lucki
  • Biology, Psychology
    The Journal of clinical psychiatry
  • 1996
TLDR
An overview of the physiology and pharmacology of serotonin systems is provided so that the relationship between serotonin compounds and anxiety can be better understood.
Antidepressant-like behavioral effects of serotonin receptor agonists
Drug-Induced Actions on Brain Neurotransmitter Systems and Changes in the Behaviors and Emotions of Depressed Patients
TLDR
Findings from this multihospital study of 104 unipolar and bipolar depressed patients showed early drug-associated reductions in anxiety and hostility in treatment responders to precede changes in motor retardation and depressed mood, suggesting tricyclics have multiple behavioral actions, that response is mediated through changes in specific behaviors.
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.
  • I. Lucki
  • Psychology, Biology
    Behavioural pharmacology
  • 1997
TLDR
The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria and should be sensitive to all antidepressant drugs and should also display multiple components that are sensitive to specific drug classes.
Hypothalamic Serotonin in Relation to Appetite for Macronutrients and Eating Disorders
TLDR
The evidence reviewed here suggests that 5-HT in the hypothalamus modulates the circadian pattern of feeding, as well as the proportion of carbohydrate in the diet, which may mediate certain symptoms of eating disorders.
Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?
The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans.
TLDR
The findings that relapse during treatment is specific to the type of treatment and type of depletion, that neither SD or CD produced an increase in clinical depression in healthy controls or depressed patients off medication, and that recovered patients off medications have a return of symptoms following SD, forces a major revision of the current monoamine theories of depression.
Modulatory role of serotonin in neural information processing: implications for human psychopathology.
  • M. Spoont
  • Psychology, Biology
    Psychological bulletin
  • 1992
Investigation of the role of 5-hydroxytryptophan (5-HT), which functions as a modulator in the central nervous system, across behavioral contexts suggests that a general principle of transmitter…
CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence.
TLDR
The original studies, which reported an association between low cerebrospinal fluid 5-hydroxyindole-acetic acid concentration and impulsive, destructive behaviors, have now been replicated rather consistently in a number of countries and cultures.
...
1
2
3
4
5
...