The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing.

@article{Lang2017TheSO,
  title={The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing.},
  author={Guan-Tian Lang and Jin-xiu Shi and Xin Hu and Chen-hui Zhang and Ling Shan and Chuan-gui Song and Zhi-gang Zhuang and A Y Cao and Hong Ling and Ke-Da Yu and Shan Li and Meng-hong Sun and Xiaoyan Zhou and Wei Huang and Zhi-Ming Shao},
  journal={International journal of cancer},
  year={2017},
  volume={141 1},
  pages={129-142}
}
To characterize the prevalence of BRCA mutations and characteristics of BRCA carriers in China and to update the clinical recommendations for BRCA testing, we conducted a wide screen for BRCA mutations using next-generation sequencing (NGS). A total of 4,034 Chinese subjects were screened for germline BRCA1/2 mutations, including 2,991 breast cancer patients and 1,043 healthy individuals from the community enrolled as controls. We developed an NGS-based approach to perform BRCA1/2 screening… CONTINUE READING
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