The spectrin repeat folds into a three-helix bundle in solution.

  title={The spectrin repeat folds into a three-helix bundle in solution.},
  author={Jaime Pascual and Mark Pfuhl and Germ{\'a}n Tenorio Rivas and Annalisa Pastore and Matti Saraste},
  journal={FEBS letters},
  volume={383 3},
Spectrin, a major component of the membrane skeleton, is mainly composed of tandemly repeated segments of approx. 106 amino acids. We have undertaken the determination of the three-dimensional structure of a chicken brain alpha-spectrin repeat by heteronuclear multidimensional NMR. Sedimentation equilibrium demonstrates that this repeat is monomeric at the concentration used for NMR (1 mM). Its secondary structure was identified using a collection of sequential and medium range NOEs, chemical… CONTINUE READING

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