The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.

@article{Hearn2009TheSO,
  title={The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.},
  author={Arron R. Hearn and Ian A. York and Kenneth L. Rock},
  journal={Journal of immunology},
  year={2009},
  volume={183 9},
  pages={
          5526-36
        }
}
Aminopeptidases in the endoplasmic reticulum (ER) can cleave antigenic peptides and in so doing either create or destroy MHC class I-presented epitopes. However, the specificity of this trimming process overall and of the major ER aminopeptidase ERAP1 in particular is not well understood. This issue is important because peptide trimming influences the magnitude and specificity of CD8 T cell responses. By systematically varying the N-terminal flanking sequences of peptides in a cell-free… CONTINUE READING
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