The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically.

@article{Glimcher1982TheSO,
  title={The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically.},
  author={L. H. Glimcher and Ronald H. Schwartz and Dan L. Longo and Alfred Singer},
  journal={Journal of immunology},
  year={1982},
  volume={129 3},
  pages={987-91}
}
In previous studies, the syngeneic MLR of peripheral T cells was shown to be predominantly an I region-restricted function. In this report we show that adult thymocytes are also capable of responding to syngeneic irradiated stimulator cells in a syngeneic MLR, provided that TCGF is added to the culture system. Using this assay, it was possible for the first… CONTINUE READING