The specificity of strychnine as a glycine antagonist in the mammalian spinal cord

@article{Curtis1971TheSO,
  title={The specificity of strychnine as a glycine antagonist in the mammalian spinal cord},
  author={Dr. Robin Curtis and Arthur William Duggan and Graham A. R. Johnston},
  journal={Experimental Brain Research},
  year={1971},
  volume={12},
  pages={547-565}
}
SummaryAn investigation was made of the influence of strychnine on the depression of the firing of spinal interneurones and Renshaw cells by glycine, GABA, nor-adrenaline and 3-hydroxytyramine. Administered electrophoretically or intravenously, strychnine blocks the effect of glycine more readily than that of the other depressants. Such specific antagonism of glycine action by relatively low concentrations of strychnine may be competitive in nature, but technical difficulties precluded a full… CONTINUE READING
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