The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.

@article{Baldwin2001TheSO,
  title={The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.},
  author={Mark. Baldwin and Bruno Catimel and Edouard Collins Nice and Sally Roufail and Nathan E. Hall and Kaye L. Stenvers and Marika J. Karkkainen and Kari Alitalo and Steven A Stacker and Marc G. Achen},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={
          19166-71
        }
}
Human vascular endothelial growth factor-D (VEGF-D) binds and activates VEGFR-2 and VEGFR-3, receptors expressed on vascular and lymphatic endothelial cells. As VEGFR-2 signals for angiogenesis and VEGFR-3 is thought to signal for lymphangiogenesis, it was proposed that VEGF-D stimulates growth of blood vessels and lymphatic vessels into regions of embryos and tumors. Here we report the unexpected finding that mouse VEGF-D fails to bind mouse VEGFR-2 but binds and cross-links VEGFR-3 as… CONTINUE READING
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