The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.

@article{Gibson1990TheSO,
  title={The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.},
  author={Greg Gibson and A nnette Schier and Peter K Lemotte and W. J. Gehring},
  journal={Cell},
  year={1990},
  volume={62 6},
  pages={1087-103}
}
The sequence requirements for distinguishing the functional specificities of two homeodomain proteins, Antennapedia and Sex combs reduced, involved in the specification of segmental identities in Drosophila, have been determined. A series of deletions and hybrid proteins was generated and assayed for their function in vivo after heat shock-induced ectopic expression during development. A distinct portion of each protein, including the residues within and adjacent to both ends of the homeodomain… CONTINUE READING

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