The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice.

@article{Ando2004TheSP,
  title={The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice.},
  author={Hitoshi Ando and Seiichiro Kurita and Toshinari Takamura},
  journal={Life sciences},
  year={2004},
  volume={74 14},
  pages={1817-27}
}
The p38 mitogen-activated protein kinase (MAPK) pathway is important in Th1 immunity, macrophage activation, and apoptosis. Since they may be associated with beta-cell destruction during the development of type 1 diabetes, we investigated the role of the p38 MAPK pathway in female nonobese diabetic (NOD) mice. Phosphorylated p38 MAPK was observed… CONTINUE READING