The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.

@article{Ekberg2007TheSM,
  title={The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat.},
  author={H. B. N. Ekberg and Zhongquan Qi and Clara P{\aa}hlman and B{\'e}la Veress and Robert V Bundick and Robert I Craggs and Elain Holness and Susan Edwards and Clare M. Murray and Douglas C. Ferguson and Philip J Kerry and Elaine Wilson and David K Donald},
  journal={Transplantation},
  year={2007},
  volume={84 9},
  pages={1191-9}
}
BACKGROUND In a search for immunosuppressive drugs having novel mechanisms, monocarboxylate transporter (MCT-1) inhibitors were identified that markedly inhibited immune responses. Here, we report the effects of AR-C117977, a potent MCT-1 inhibitor, on alloimmune responses in the rat. METHODS In vitro activity was determined in a rat mixed lymphocyte response (MLR). In vivo activity was tested in a graft versus host response (GVHR) and in both high (DA to PVG) and low (PVG to DA) responder… CONTINUE READING

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