The specific induction of osteosarcomas in different mouse strains after injections of 239Pu citrate.

@article{Oghiso2003TheSI,
  title={The specific induction of osteosarcomas in different mouse strains after injections of 239Pu citrate.},
  author={Yoichi Oghiso and Yutaka Yamada},
  journal={Journal of radiation research},
  year={2003},
  volume={44 2},
  pages={125-32}
}
Lifetime bone tumor induction by the injection of a bone-seeking alpha emitter, 239Pu citrate, was compared among 630 female mice from three strains (C3H/He, C57BL/6 and B6C3F1) showing different genetic backgrounds for carcinogenesis. Bone tumors, mostly osteosarcomas, appeared early during the period from 200 to 600 days after the injection, showing an almost similar dose responsiveness with a peak incidence of 50% to 63% at skeletal doses of 2-3 Gy, in all mouse strains. The primary sites of… CONTINUE READING