The special delivery of a tail-anchored protein: why it pays to use a dedicated courier.

@article{Brodsky2010TheSD,
  title={The special delivery of a tail-anchored protein: why it pays to use a dedicated courier.},
  author={Jeffrey L Brodsky},
  journal={Molecular cell},
  year={2010},
  volume={40 1},
  pages={5-7}
}
The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pathway.