The spatio-temporal arrangement of different tissues during bone healing as a result of simple mechanobiological rules.

@article{Vetter2012TheSA,
  title={The spatio-temporal arrangement of different tissues during bone healing as a result of simple mechanobiological rules.},
  author={Andreas Vetter and Florian Witt and Oliver Sander and Georg N. Duda and Richard Weinkamer},
  journal={Biomechanics and modeling in mechanobiology},
  year={2012},
  volume={11 1-2},
  pages={147-60}
}
During secondary bone healing, different tissue types are formed within the fracture callus depending on the local mechanical and biological environment. Our aim was to understand the temporal succession of these tissue patterns for a normal bone healing progression by means of a basic mechanobiological model. The experimental data stemmed from an extensive, previously published animal experiment on sheep with a 3 mm tibial osteotomy. Using recent experimental data, the development of the hard… CONTINUE READING
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