The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.

@article{Porter1998TheSO,
  title={The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.},
  author={John David Henley Porter and J. A. S. Rafael and R J Ragusa and Jennifer K. Brueckner and Jeffrey I. Trickett and K. E. Davies},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 13)},
  pages={1801-11}
}
The extraocular muscles are one of few skeletal muscles that are structurally and functionally intact in Duchenne muscular dystrophy. Little is known about the mechanisms responsible for differential sparing or targeting of muscle groups in neuromuscular disease. One hypothesis is that constitutive or adaptive properties of the unique extraocular muscle phenotype may underlie their protection in dystrophinopathy. We assessed the status of extraocular muscles in the mdx mouse model of muscular… CONTINUE READING