The soy isoflavone genistein inhibits the reduction in Achilles tendon collagen content induced by ovariectomy in rats.

@article{Ramos2012TheSI,
  title={The soy isoflavone genistein inhibits the reduction in Achilles tendon collagen content induced by ovariectomy in rats.},
  author={Joseba Ezeiza Ramos and Layla Al-Nakkash and Amity Peterson and Brian S. Gump and Tea Janjulia and M S Moore and Tom L Broderick and Chad C. Carroll},
  journal={Scandinavian journal of medicine & science in sports},
  year={2012},
  volume={22 5},
  pages={
          e108-14
        }
}
The objective of this study was to evaluate the effects of genistein and moderate intensity exercise on Achilles tendon collagen and cross-linking in intact and ovariectomized (OVX) female Sprague-Dawley rats. Rats were separated into eight groups (n = 9/group): intact or OVX, treadmill exercised or sedentary, genistein-treated (300 mg/kg/day) or vehicle. After 6 weeks, tendons were assayed for the collagen-specific amino acid hydroxyproline and hydroxylyslpyridinoline (HP). Collagen content… CONTINUE READING
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