The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.

@article{Vig2006TheSO,
  title={The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice.},
  author={Pamela Vig and Francesco P Russo and Robert J. Edwards and Paul J. Tadrous and Nicholas Anthony Wright and Howard Thomas and Malcolm R Alison and Stuart J Forbes},
  journal={Hepatology},
  year={2006},
  volume={43 2},
  pages={316-24}
}
After liver injury, parenchymal regeneration occurs through hepatocyte replication. However, during regenerative stress, oval cells (OCs) and small hepatocyte like progenitor cells (SHPCs) contribute to the process. We systematically studied the intra-hepatic and extra-hepatic sources of liver cell replacement in the hepatitis B surface antigen (HBsAg-tg) mouse model of chronic liver injury. Female HBsAg-tg mice received a bone marrow (BM) transplant from male HBsAg-negative mice, and half of… CONTINUE READING