The sources of pain in osteoarthritis: a pathophysiological review.

  title={The sources of pain in osteoarthritis: a pathophysiological review.},
  author={Fausto Salaffi and Alessandro Ciapetti and Marina Carotti},
  volume={66 1},
The pain of osteoarthritis (OA) has multifaceted etiologies within and outside the joint. It is believed to be driven by both nociceptive and neuropathic mechanisms, as well as abnormal excitability in the pain pathways of the peripheral and central nervous system. Inflammation in the joint triggers a cascade of events that leads to peripheral sensitization, increased sensitivity of nociceptive primary afferent neurons, and hyperexcitability of the nociceptive neurons in the central nervous… CONTINUE READING
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