The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen.

@article{Igarashi2003TheSO,
  title={The sortase of Streptococcus mutans mediates cell wall anchoring of a surface protein antigen.},
  author={Takeshi Igarashi and Emiko Asaga and Nobuichi Goto},
  journal={Oral microbiology and immunology},
  year={2003},
  volume={18 4},
  pages={266-9}
}
Sortase has been shown to be a protease that catalyzes the cell wall anchoring of surface proteins containing an LPXTG motif in gram-positive bacteria. In this study, we determined the complete nucleotide sequence of the sortase gene (srtA) of Streptococcus mutans and found a surface protein that was linked to the cell wall by the sortase. The results show that srtA gene of S. mutans consisted of 741 bp and encoded for a sortase protein of 246 amino acids with a molecular weight of 27 489. The… CONTINUE READING

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