The somatotropic axis and aging: Benefits of endocrine defects.

@article{Bartke2016TheSA,
  title={The somatotropic axis and aging: Benefits of endocrine defects.},
  author={Andrzej Bartke and Edward O. List and John J. Kopchick},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2016},
  volume={27},
  pages={41-45}
}
Reduced somatotropic [growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] action has been associated with delayed and slower aging, reduced risk of frailty, reduced age-related disease and functional decline, and with remarkably extended longevity. Recent studies have added to the evidence that these relationships discovered in laboratory populations of mice apply to other mammalian species. However, the relationship of the somatotropic signaling to human aging is less striking… CONTINUE READING
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