The somatostatin immunoregulatory circuit present at sites of chronic inflammation.

@article{Weinstock2000TheSI,
  title={The somatostatin immunoregulatory circuit present at sites of chronic inflammation.},
  author={Joel V. Weinstock and David E. Elliott},
  journal={European journal of endocrinology},
  year={2000},
  volume={143 Suppl 1},
  pages={S15-9}
}
Somatostatin is part of an immunoregulatory circuit that helps limit interferon-gamma (IFNgamma) production at sites of chronic inflammation. In murine schistosomiasis. parasite eggs induce focal, chronic granulomatous inflammation in the liver and intestines. These granulomas produce somatostatin 1-14 and express somatostatin receptor subtype number 2 (SSTR2), which is the exclusive somatostatin receptor present in this inflammation. Granuloma and splenic macrophages as well as macrophage cell… CONTINUE READING